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Študijný program  všeobecné lekárstvo 

Organizácia výučby a skúšok

Harmonogram výučby a rozvrh

Výberové prednášky a semináre

Sylaby (otázky) (patologická fyziológia)

Voliteľné predmety (3.-6.ročník) 

OZNAMY - výučba, skúšky


Odporúčaná literatúra

Študijný program zubné lekárstvo 

Organizácia výučby a skúšok
Harmonogram výučby a rozvrh
Sylaby(otázky) (patologická fyziológia)

OZNAMY - výučba, skúšky


Odporúčaná literatúra

Študijný program biomedicínska fyzika

Harmonogram výučby a rozvrh

Sylaby látky      

Odporúčaná literatúra

Study programme General medicine
(English  speaking students)

Study rules and integral organization

Program of seminars and practical lessons + time schedule

Sylabus (questions) (Pathologic physiology)        

NEWS - credits and exams

Optional subjects

Study Literature  


Study programme Dentistry 
(English  speaking students)

Study rules and integral organization

Program of seminars and practical lessons + time schedule

Sylabus (questions) (Pathologic physiology)    

NEWS - credits and exams

Optional subjects

Study Literature 





  Study programme  Dentistry

   Sylabus ( questions) of pathologic physiology  (2016)


General pathophysiology

 1.   Inflammation – acute and chronic (answer to damage of cells, the phases of  
   inflammation, cells and mediators participating on inflammation).

 2.   Fever – definition, pathogenesis, course and symptoms, classification.

 3.   Sepsis (definition, pathogenesis, manifestation).

 4.   Apoptosis (molecular mechanisms, signalization, induction, regulation and timing 
    of apoptosis,  differences from necrosis).

 5.   The task of immune system in the defence of organism (nature, participating 
   cells, regulatory mechanisms).

 6.   Immunodeficiency (primary, secondary).

 7.   Immune hypersensitivity  and autoimmune diseases.

 8.   Monogenic  disorders (cystic fibrosis, muscular dystrophies, malignant tumors).

 9.   Cellular signal-transduction pathways.

10.  Dehydration (isotonic, hypertonic, hypotonic).

11.  Hyperhydration (isotonic, hypertonic, hypotonic).

12.  Disorders of acid-base balance.

13.  Metabolic and respiratory acidosis and alkalosis.

14.  Pain (etiology, pathogenesis, biological implications, classification).

15.  Oedema (interstitial, intracellular, pathogenetic factors, biological implications).

16.  Stress (definition, term stress and stressor, homeostasis, humoral and 
   hemodynamic changes in stress).

17.  Stress and diseases of civilisation (pathogenesis of functional disorders, 
   corticovisceral theory, adaptation to stress).

18.  Ionic inbalance (sodium, potassium, calcium, magnesium).

19.  Hypoxemia (pathogenesis, types, clinical manifestations, compensatory 

20.  Carcinogenesis (malignant transformation, autonomy of tumours, disorder of 
   growth regulation, angiogenesis, invasive metastatic growth).


  Cardiovascular system

21.  Regulatory mechanism of the contractile heart activity (preload, contractility, 
    afterload, heart rate, synergism of contraction).

22.  Heart failure (definition, classification, pathogenesis, compensatory mechanisms, 
    circle vicious).

23.   Heart failure – pathogenesis of clinical signs and symptoms.

24.   Heart failure – pathophysiological principles of therapy.

25.   Heart failure – right heart failure.

26.   Hypertrophy of the heart (pathogenesis, classification, ambivalent nature, 

27.   Cardiomyopathies – (definition, classification, dilated and hypertrophic 

28.   Mitral stenosis and insufficiency.

29.   Aortic stenosis and insufficiency.

30.   Congenital heart diseases (without cyanosis and with possible cyanosis).

31.   Congenital heart diseases (with cyanosis).

32.   Endocarditis (infective and rheumatic).

33.   Endothelial dysfunction (etiology, disorders of vascular tone, relation to 

34.   Pathogenesis of atherosclerosis (cells, pathomechanisms, clinical 

35.   Stabile and unstable atherosclerotic plaque.

36.   Ischemic heart disease (physiology of coronary circulation, stabile and unstable 
     angina pectoris).

37.   Myocardial infarction ( pathogenesis, manifestation, complications, diagnostic).

38.   Pathomechanism of the reperfusion heart damage (calcium paradox, oxygen 
    paradox, clinical implications).

39.   Dysrhythmias- supraventricular extrasystole, tachycardia, fibrillation and flutter.

40.   Dysrhythmias – ventricular extrasystoles, tachycardia, fibrillation and flutter.

41.   AV blockades.

42.   Sudden cardiac death (definition, etiology, pathogenesis, arhythmogenic and 
     non-arhythmogenic SCD).

43.   Blood pressure  (determinants  of BP, regulatory mechanisms, arterial pulse).

44.   Systemic arterial hypertension  - essential (formal pathogenesis, etiologic and 
      pathogenetic factors, value of optimal, normal and pathologic blood pressure).

45.   Hypertension and peripheral organ damage (heart, vessels, brain, kidneys).

46.   Secondary hypertensions. 

47.   Collapse (definition, classification, pathogenesis, signs and symptoms).

48.   Shock – pathogenesis, classification, clinical manifestations, compensatory 

49.   Hypovolemic shock.

50.   Septic shock.

51.   Cardiogenic shock.

52.   Pulmonary oedema.

53.   Pulmonary hypertension and pulmonary embolism.

54.   Cor pulmonale - acute and chronic.

55.   Disorders of venous system (varices, chronic venous insufficiency, superficial and 
    deep thrombosis).

56.   Cardiovascular risk factors (internal, external, classification, score systems).


   Uropoetic system

57.    Proteinuria and nephrotic syndrome.

58.    Hematuria and nephritic syndrome.

59.    Acute renal failure.

60.    Chronic renal failure.

61.    Interstitial nephritis.

62.    Glomerulonephritis.


   Gastrointestinal system

63.    Ulcer disease of stomach and duodenum.

64.    Disorders of oesophagus.

65.    Liver cirrhosis.

66.    Liver insufficiency.

67.    Acute and chronic pancreatitis.

68.    Inflammatory bowel diseases.

69.    Ileus.

70.    Diarrhoea and constipation.

71.    Malabsorption syndrome.


   Central nervous system

72.    Brain ischemia and stroke (ischemic and haemorrhagic stroke, pathogenesis, 

73.    Intracranial hypertension and oedema.

74.    Degenerative disorders of CNS.


   Endocrine system

75.    Hyperthyroidism.

76.    Hypothyroidism.

77.    Cushing disease.

78.    Adisson disease.

79.    Adrenogenital syndrome.

80.    Pheochromocytoma.

81.    Hyper- and hypoparathyroidism.

82.    Disorders of hypothalamus.

83.    Disorders of hypophysis.

84.    Pubertas and pseudopubertas praecox.

85.    Diabetes mellitus type 1 – classification, manifestations, pathogenesis.

86.    Diabetes mellitus type 2 – classification, manifestations, pathogenesis.

87.    Complications of diabetes mellitus (acute and chronic).

88.    Metabolic syndrome and insulin resistance.

89.    Obesity (definition, pathomechanism, manifestation).

90.    Disorders of calcium metabolism and osteoporosis.


   Respiratory system

91.    Dyspnoe (definition, pathogenesis, classification).

92.    Disorders of ventilation, diffusion and perfusion, ventilation-perfusion imbalance.

93.    Respiratory insufficiency  acute and chronic (definition, pathogenesis, 

94.    Pneumonia (definition, classification, pathogenesis and manifestations).

95.    Interstitial lung diseases (definition, classification, pathogenesis,  


   Pathophysiology of blood

96.   Anemic syndrome (definition, classification, pathogenesis and clinical 

97.   Posthemorrhagic  anaemias (acute and chronic). 

98.   Hemolytic anaemias.

99.   Sideropenic anaemias.

100.  Megaloblastic anaemias.

101.  Anaemias in secondary diseases.

102.  Disorders of white blood cells (infections, leucemias,  lymphomas).

103.  Disorders of thrombocytes and vascular purpura.

104.  Disseminated intravascular coagulation.


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